Antigen-binding molecule for promoting disappearance of antigen via FcyRIIB

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专利权人:

Chugai Seiyaku Kabushiki Kaisha

发明人:

IGAWA, Tomoyuki,MAEDA, Atsuhiko,IWAYANAGI, Yuki,HARAYA, Kenta,KATADA, Hitoshi,KADONO, Shojiro,MIMOTO, Futa

申请号：

AU2018202643

公开号：

AU2018202643A1

申请日:

2018.04.16

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

#$%^&*AU2018202643A120180510.pdf#####ABSTRACT The present invention provides antigen-binding molecules containing (i) an antigen binding domain whose antigen-binding activity varies depending on ion concentration conditions, (ii) an Fcy-binding domain having Fey RIlb-selective binding activity, 5 and (iii) an FcRn-binding domain having FcRn-binding activity under an acidic pH range condition, and methods of decreasing plasma antigen concentration as compared to before administering the molecule, which include the step of administering the molecule.

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中国工程科技知识中心

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http://www.ckcest.cn/home/