PROBLEM TO BE SOLVED: To provide an antigen-binding molecule targeting a novel epitope in RNF43, and to provide a multispecific antigen-binding molecule capable of treating cancer by having T cells close to cells expressing RNF43. The present disclosure provides an antigen-binding molecule comprising a first antigen-binding domain having RNF43 binding activity. The present disclosure also provides a multispecific antigen binding molecule comprising a first antigen binding domain having RNF43 binding activity and a second antigen binding domain having T cell receptor complex binding activity. The method for producing such an antigen-binding molecule also provides use of a pharmaceutical composition, an antigen-binding molecule and the like containing such an antigen-binding molecule. [Selection diagram] None【課題】RNF43内の新規エピトープを標的とする抗原結合分子の提供、及び、RNF43発現細胞に近いT細胞を有することによって癌治療を可能にする多重特異性抗原結合分子の提供。【解決手段】本開示は、RNF43結合活性を有する第1の抗原結合ドメインを含む抗原結合分子を提供する。本開示はまた、RNF43結合活性を有する第1の抗原結合ドメインおよびT細胞受容体複合体結合活性を有する第2の抗原結合ドメインを含む多重特異性抗原結合分子を提供する。このような抗原結合分子の製造方法には、このような抗原結合分子を含む医薬組成物、抗原結合分子等の用途も提供される。【選択図】なし
