Problem to be solved: to provide an anti-CD137 antigen binding molecule with low activity and a low side effect, and use of the anti-CD137 antigen molecule which has the activation action, the cytotoxic activity, or the antitumor activity of the immune cell, and the non tumor organization such as normal tissue.Solution: an anti-CD137 antigen binding molecule having CD137 binding activity dependent on a small molecule compound, an isolated nucleic acid encoding an antigen binding molecule, a host cell comprising the nucleic acid, a method of producing the antigen binding molecule, and an immunoconjugate comprising the antigen binding molecule and cytotoxic agent.No selection【課題】免疫細胞の活性化作用、細胞傷害活性、または抗腫瘍活性を有しながら、正常組織等の非腫瘍組織に対する作用が低く、副作用が少ない抗CD137抗原結合分子、およびそれらを使用する方法の提供。【解決手段】低分子化合物に依存したCD137結合活性を有する抗CD137抗原結合分子、抗原結合分子をコードする単離された核酸、該核酸を含む宿主細胞、該抗原結合分子を製造する方法、ならびに該抗原結合分子および細胞傷害剤を含むイムノコンジュゲート。【選択図】なし
