Antigen-binding molecule for promoting disappearance of antigen via FcgammaRIIb

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专利权人:

Chugai Seiyaku Kabushiki Kaisha

发明人:

Igawa, Tomoyuki,Maeda, Atsuhiko,Iwayanagi, Yuki,Haraya, Kenta,Katada, Hitoshi,Kadono, Shojiro,Mimoto, Futa

申请号：

AU2013223087

公开号：

AU2013223087A1

申请日:

2013.02.22

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The invention provides: an antigen-binding molecule containing (i) an antigen-binding domain for changing the binding activity in relation to an antigen depending on the conditions of ion concentration, (ii) an Fcγ-binding domain having FcγRIIb selective binding activity, and (iii) an FcRn-binding domain having binding activity in relation to FcRn under the conditions of a pH acidic region； and a method for lowering the concentration of an antigen in the plasma in comparison with before administration of the molecule, the method comprising administering the molecule.

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中国工程科技知识中心

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http://www.ckcest.cn/home/