As for this invention the new displacement benzo flow chromene and the related chemical compound which are displayed with general formula (i), in regard to salt, kiraru and the kiraru derivative, as for1 R,2 R,3 R,4 R,5 R,6 R,7 R and8 R, haidoroThe gene, alkyl, arukeniru displacement optionally and displacement optionally the alkoxyl displacement optionally, the aryl displacement optionally and the heteroaryl displacement optionally, alkyl thio displacement optionally, amino, the acylamino displacement optionally and displacement optionally the arylamino displacement optionally, acyl thio displacement optionally, acyl displacement optionally and aroiru displacement optionally, optionally displacement the thio amide displacement acyloxy and optionally, halogen, nitrile, ester, hydroxy, merukaputo and three fluoridation carbons, nitro, it is respectively chosen from the group which consists of, but it does not limit to this. R1,2 R or2 R,3 R or6 R and7 R joining, may form either five membered-rings or six membered-rings of furan, jihidorohuran displacement optionally and displacement optionally the pyrane etc displacement optionally and, through the methylene dioxy part, it is possible to join. X is chosen from one group which consists of the ketone group, the methylene group, the methylene group displacement optionally and the alkene group displacement optionally. Y and Z is chosen from the group which consists of CH, C-OH, C-Me and C-OMe. However, the join of Y and Z is single bond. YAnd Z may be the carbon atom. However, the join of Y and Z is double bond. The chemical compound which is displayed with the above-mentioned general formula is useful in prevention and remedy of the bone-related disease.本発明は一般式(I)で表される新規な置換ベンゾフロクロメン及び関連化合物、塩、キラル、キラル誘導体に関し、R1、R2、R3、R4、R5、R6、R7、R8 は、ハイドロゲン、任意に置換されたアルキル、任意に置換されたアルケニル、任意に置換されたアルコキシル、任意に置換されたアリール、任意に置換されたヘテロアリール、任意に置換されたアルキルチオ、任意に置換されたアミノ、任意に置換されたアシルアミノ、任意に置換されたアリールアミノ、任意に置換されたアシルチオ、任意に置換されたアシル、任意に置換されたアロイル、任意に置換されたアシルオキシ、任意
