The present invention relates to novel antagonizing antibodies for CD73. The invention also relates to nucleic acids encoding such antibody molecules; to methods for preparing such antibody molecules; to host cells expressing or capable of expressing such antibody molecules; to compositions comprising such antibody molecules; and to uses of such antibody molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.本發明係關於CD73之新穎拮抗抗體。本發明亦關於編碼該等抗體分子之核酸;製備該等抗體分子之方法;表現或能夠表現該等抗體分子之宿主細胞;包括該等抗體分子之組合物;及該等抗體分子或該等組合物之用途,尤其用於癌症疾病領域中之治療目的。