Nucleic acid molecule capable of inhibiting expression of periostin gene, method for inhibiting expression of periostin gene, and use of said nucleic acid molecule农业专利-农业专业知识服务系统

发明人:: YOSHIDA, SHIGEO,吉田茂生,吉田茂生,HAMASAKI, TOMOHIRO,滨崎智洋,濱崎智洋,ISHIKAWA, KEIJIRO,石川桂二郎,石川桂二郎,MIZUTANI, TAKAYUKI,水谷隆之,水谷隆之,ISHIBASHI, TATSURO,石桥达朗,石橋達朗,OHGI, TADAAKI,大木忠明,大木忠明,NAKAMA, TAKAHITO,中间崇仁,中間崇仁

摘要：: Provided is a novel molecule which can inhibit the expression of periostin gene. A nucleic acid molecule capable of inhibiting the expression of periostin gene is characterized by containing nucleotides that constitute at least one nucleotide sequence selected from the nucleotide sequences represented by SEQ ID NOs: 1 to 19 as a sequence capable of inhibiting the expression of periostin gene. The nucleic acid molecule capable of inhibiting the expression according to the present invention can inhibit the expression of periostin gene. Therefore, the nucleic acid molecule can be used for the treatment of eye diseases associated with the expression of periostin gene, specifically proliferative diabetic retinopathy, macular degeneration and the like.本發明提供一種抑制成骨細胞特異因子基因之表現的新分子。成骨細胞特異因子基因之表現抑制核酸分子特徵在於:包含由序列編號1~19中任一鹼基序列所構成之核苷酸來作為成骨細胞特異因子基因之表現抑制序列。依據本發明之表現抑制核酸分子,由於可抑制成骨細胞特異因子基因之表現的緣故,而可使用於諸如以成骨細胞特異因子基因之表現為成因之眼部疾病,具體來說則可使用於增生性糖尿病視網膜病變及黃斑部病變等之治療。