SKWIERCZYNSKI, RAYMOND D.,BUSCH, TERRI, F.,GUST-HEITING, AMY, L.,FRETLAND, MARY, T.,SCHOLZ, MATTHEW, T.
申请号：
HRP20040474
公开号：
HRP20040474B1
申请日:
2004.05.27
申请国别(地区):
HR
年份:
2014
代理人:
摘要：
Pharmaceutical formulations comprising an immune response modifier (IRM) chosen from imidazoquinoline amines, imidazotetrahydroquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo-quinolineamines, oxazolo-quinolinamines, thiazolo-pyridinamines, oxazolo-pyridinamines, imidazonaphthyridine amines, tetrahydroimidazonaphthyridine amines, and thiazolonaphthyridine amines； a fatty acid； and a hydrophobic, aprotic component miscible with the fatty acid are useful for the treatment of dermal associated conditions. Novel topical formulations are provided. In one embodiment, the topical formulations are advantageous for treatment of actinic keratosis, postsurgical scars, basal cell carcinoma, atopic dermatitis, and warts.Farmaceutska formulacija koja sadrže modifikator imunog odgovora (IRM) koji odabran od sljedećih: imidazokinolin-amini, imidazotetrahidrokinolin-amini, imizadopiridin-amini, 6,7-fuzioniranih cikloalkilimidazopiridin-amini, 1,2-premošteni imidazokinolin-amini, tiazolokinolin-amini, oksazolokinolin-amini, tiazolopiridin-amini, oksazolopiridin-amini, imidazonafthidrin-amini, imidazotetrahidronafthidrin-amini i tiazolonafthidrin-amini； masnu kiselinu； hidrofobnu aprotonsku komponentu koja se miješa s masnom kiselinom, a koja je korisna za tretman stanja kože. Prikazane su nove topičke formulacija. U jednoj cjelini topičke formulacije su pogodne za tretman aktinske keratoze, postoperativnih ožiljaka, karcinoma bazalnih stanica, atopičnog dermatitisa i bradavica.
