Provided are compounds of Formula I, stereoisomers, tautomers, solvates, prodrugs and pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, and methods of manufacturing a compound of Formula I.本發明提供式I化合物、其立體異構體、互變異構體、溶劑合物、前藥及醫藥學上可接受之鹽(其中A、X、R1、R2、R4及R5係如本文中定義),包括式I化合物及醫藥學上可接受之載劑、佐劑或媒劑的醫藥組合物,在療法中使用該化合物或組合物之方法,及製造式I化合物之方法。
