VARIANTS D'ANTICORPS PRÉSENTANT DES MODIFICATIONS DANS LA RÉGION CONSTANTE
- 专利权人:
- Genmab A/S
- 发明人:
- 申请号:
- EP16185985.5
- 公开号:
- EP3153524A1
- 申请日:
- 2009.12.03
- 申请国别(地区):
- EP
- 年份:
- 2017
- 代理人:
- 摘要:
- The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
- 来源网站:
- 中国工程科技知识中心
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