The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of lgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.La présente invention concerne des positions dans la région constante danticorps, en particulier la région CH3 de lgG4, qui affectent la force des interactions CH3-CH3. Linvention concerne des mutations qui stabilisent ou déstabilisent cette interaction.
