Aran Frank Labrijn,Stefan Loverix,Paul Parren,Jan Van De Winkel,Janine Schuurman,Ignace Lasters
申请号：
US15977725
公开号：
US20180319888A1
申请日:
2018.05.11
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
