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Phenoxychroman carboxylic acid derivatives substituted in 6
专利权人:
ARRAY BIOPHARMA; INC.
发明人:
BURGESS, LAURENCE,CLARK, CHRISTOPHER,COOK, ADAM,CORRETTE, CHRISTOPHER,DELISLE, ROBERT,DOHERTY, GEORGE,HUNT, KEVIN,ROMOFF, TODD,KIM, GANGHYEOK
申请号:
ES09770959
公开号:
ES2524314T3
申请日:
2009.06.24
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compound of general formula I: ** Formula ** or a salt thereof, wherein: A1 is hydrogen, CN, Cl, F, Br, OMe, (C1-4 alkyl) or cyclopropyl; A2 is hydrogen, Cl, Br, F, (C1-4 alkyl) or cyclopropyl; W is -C (>; = O) NR1- or -NR2C (>; = O) -; R1 and R2 are each hydrogen or methyl; L is a bond, - (CR3R4) n- (CRaRb) m- (CR5R6) - *, (C2-4) alkenylene, -O (C1-4 alkyl) - *, - (C1-4 alkyl) - O- *, - (C1-4 alkyl) -S - *, C3-6 cycloalkylene, or hetCyc1, in which * indicates the point of attachment to G, with the proviso that when W is -NR2C ( >; = O) -; then L is not - (CH>; = CH) -; m>; = 0, 1 or 2; n>; = 0 or 1; Ra and Rb are independently selected from hydrogen and (C1-4 alkyl); R3 is hydrogen, (C1-4 alkyl) or CH2OH; R4 is hydrogen or methyl; R5 is hydrogen, (C1-4 alkyl), OH, -O (C1-4 alkyl) or F; R6 is hydrogen, F or methyl, or R5 and R6, together with the carbon to which they are attached, form a cyclopropyl ring, hetCyc1 is a group that has the formula in which t is 1 or 2 and p is 0 or 1, and * indicates the point of attachment to G; G is Ar1, Ar2, naphthyl, a benzocondensed (C5-6) cycloalkyl ring optionally substituted with one or more substituents independently selected from Cl and OMe, a 5-6 membered heterocyclic ring benzocondensate having 1-2 heteroatoms independently selected from O and N, a (C3-6) cycloalkyl ring optionally substituted with one or more substituents independently selected from (C1-4) alkyl, an oxaspirononanyl ring, or t-butyl.Compuesto de fórmula general I:**Fórmula** o una sal del mismo, en la que: A1 es hidrógeno, CN, Cl, F, Br, OMe, (alquilo de C1-4) o ciclopropilo; A2 es hidrógeno, Cl, Br, F, (alquilo de C1-4) o ciclopropilo; W es -C(>;=O)NR1- o -NR2C(>;=O)-; R1 y R2 son cada uno hidrógeno o metilo; L es un enlace, -(CR3R4)n-(CRaRb)m-(CR5R6)-*, alquenileno (C2-4), -O(alquilo de C1-4)-*, -(alquilo de C1-4)-O- *, -(alquilo de C1-4)-S-*,cicloalquileno (C3-6), o hetCyc1, en los que * indica el punto de unión a G, con la condición de q
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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