PROBLEM TO BE SOLVED: To provide a pharmaceutical compound that can treat or prevent stress urinary incontinence based on 5-HT2C receptor operation activity that has promoting action on a urethral continence reflex mechanism.SOLUTION: The present invention provides a hexahydro-1,4-diazepine derivative represented by formula (I) or a pharmaceutically acceptable acid addition salt thereof (R1 is hydrogen, C1-C6 alkyl, halogen or nitrile R2 is hydrogen, C1-C6 alkyl or halogen).SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】尿禁制反射機構に対し促進的に作用する5-HT2C受容体作動活性に基づいた腹圧性尿失禁を治療又は予防できる医薬化合物の提供。【解決手段】式(I)で表されるヘキサヒドロ-1,4-ジアゼピン誘導体又はその薬学的に許容される酸付加塩。(R1は水素、炭素数1~6のアルキル、ハロゲン又はニトリル;R2は水素、炭素数1~6のアルキル又はハロゲン)【選択図】なし
