New catechol derivatives

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专利权人:

キッセイ薬品工業株式会社

发明人:

石川 健宏,井上 仁史,小林 聡子,吉田 正子,塩原 寛明,上野 康徳,田中 信之

申请号：

JP2009547092

公开号：

JP5279728B2

申请日:

2008.12.22

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R 1 and R 2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like； R 3 is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl,optionallysubstituted arylcarbonyl,lower alkoxycarbonyl or the like； R 4 is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

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http://www.ckcest.cn/home/