Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (LAG-3)

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专利权人:

APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

发明人:

BIFFONI MAURO,PAPOIAN RUBEN

申请号：

US19990319147

公开号：

US6500422(B2)

申请日:

1999.12.01

申请国别(地区):

美国

年份:

2002

代理人:

摘要：

A method to prevent graft rejection of transplanted cells, tissues or organs without general immunosuppression is described. The method employs a newly discovered protein, LAG-3. When allogeneic or xenogeneic cells are engineered to express LAG-3 on their surface and transplanted, immune destruction of the implanted cell, tissue or organ is prevented, while the host's immune system remains functional. A particular application of this method allows the preparation of a universal gene therapy host cell expressing LAG-3 on its surface for protection from graft rejection by a host's immune system.

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