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Nilotinib salts and crystalline forms thereof
专利权人:
Teva Pharmaceutical Industries Ltd.
发明人:
PIRAN, Maytal,RENDELL, Jacob
申请号:
ES11728501
公开号:
ES2555263T3
申请日:
2011.06.21
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A crystalline form of nilotinib L-tartrate selected from: a) Crystalline Form I of nilotinib L-tartrate, characterized by data selected from among: a powder X-ray diffraction pattern that has peaks at 9, 4, 11.7, 12.7, 18.2 and 19.0 degrees two theta ± 0.2 degrees two theta or a powder X-ray diffraction pattern substantially as depicted in Figure 5; b) Crystalline Form II of nilotinib L-tartrate, characterized by data selected from: a powder X-ray diffraction pattern that has peaks at 8.7, 15.7, 17.2, 19.4 and 20.0 degrees two theta ± 0.2 degrees two theta or a powder X-ray diffraction pattern substantially as depicted in Figure 6; c) Crystalline Form III of nilotinib L-tartrate, characterized by data selected from: a powder X-ray diffraction pattern that has peaks at 8.2, 9.1, 12.3, 15.0 and 17.6 degrees two theta ± 0.2 degrees two theta or a powder X-ray diffraction pattern substantially as depicted in Figure 7; d) Crystalline Form IV of nilotinib L-tartrate, characterized by data selected from: a powder X-ray diffraction pattern that has peaks at 13.6, 18.3, 19.5, 21.9 and 24.3 degrees two theta ± 0.2 degrees two theta or a powder X-ray diffraction pattern substantially as depicted in Figure 8; e) Crystalline Form V of nilotinib L-tartrate, characterized by data selected from: a powder X-ray diffraction pattern that has peaks at 3.6, 7.6, 14.1, 17.8 and 19.5 degrees two theta ± 0.2 degrees two theta or a powder X-ray diffraction pattern substantially as shown in Figure 9 and f) Crystal Form VI of nilotinib L-tartrate, characterized by selected data of between: a powder X-ray diffraction pattern that has peaks at 4.7, 12.1, 16.3, 21.0 and 24.4 degrees two theta ± 0.2 degrees two theta or a pattern of X-ray powder diffraction substantially as depicted in Figure 10.Una forma cristalina del L-tartrato de nilotinib seleccionada de entre: a) la Forma Cristalina I del L-tartrato de nilotinib, caracterizada por unos datos seleccionados de entre: un patrón de difracción d
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