Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts

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专利权人:

Apicore US LLC

发明人:

Ravishanker Kovi,Jayaraman Rao Kannapan,Ananda Babu Thirunavakarasu,Veerabhadra Rao Bobbili,Gaurav Yadav

申请号：

US15854458

公开号：

US10519121B2

申请日:

2017.12.26

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Processes are disclosed for making vortioxetine and pharmaceutically acceptable salts thereof. A propylene glycol solvate of vortioxetine hydrobromide is disclosed. A novel crystalline form of vortioxetine hydrobromide propylene glycol solvate, designated form AC1, is disclosed along with a method for making same. Form AC1 may be characterized by an x-ray powder diffraction pattern with peaks at about 19.64, 22.85, 25.51, 29.57, 30.18±0.2 degrees 2-theta.

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