Pharmaceutically acceptable propylene glycol solvate of naproxen

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专利权人:

Mark Tawa

发明人:

Mark Tawa,Örn Almarsson,Julius Remenar

申请号：

US12839550

公开号：

US08183290B2

申请日:

2010.07.20

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The invention relates to pharmaceutical compositions comprising propylene glycol solvates of APIs. In particular a 2:1 complex of naproxen sodium to propylene glycol is disclosed which is a crystalline solid. The complex is prepared by crystallization of a mixture of naproxen sodium and propylene glycol from diethyl ether. It is identifiable by its X-ray powder diffraction pattern described herein.

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