SALES DE DISACARINA, ACIDO DIFUMARICO, ACIDO D-1-HIDROXI-2-NAFTOICO Y MONOBENZOICO DEL 2-(4-((2-AMINO-4-METIL-6-(PENTILAMINO) PIRIMIDIN-5-IL) METIL) FENIL) ACETATO DE 4-(DIMETILAMINO) BUTILO
BENNETT, NICHOLAS JAMES,MCINALLY, THOMAS,PIMM, AUSTEN,THOM, STEPHEN,ISOBE, YOSHIAKI
申请号：
PE0020022011
公开号：
PE09892012A1
申请日:
2011.05.20
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a disacarina difumarico Salt, acid, acid di - 1 - hydroxy - 2 - naftoico monobenzoico acid or 2 - (4 - ((2 - amino - 4 - methyl - 4 - (pentilamino) pyrimidin-5-yl) methyl) phenyl) acetate Butyl 4 - (dimethylamino).It is also referred to as Crystalline salts of this Compound such as: (a) the shape of the Salt disacarina presents a pattern of x-ray Powder diffraction with a specific Peak at 2 Theta equals 9,2\u00ba, 14,9\u00ba or 15,2\u00ba, (b) The B form of Salt disacarina presents a pattern of difracc Ion x-ray Powder with a specific Peak at 2 Theta equals 12,0\u00ba, 12% 16,4\u00ba or 19,8\u00ba,(c) The Salt of acid difumarico presents a pattern of x-ray Powder diffraction with a specific Peak at 2 Theta like a9,1\u00ba, 14,2\u00ba, 15,8\u00ba or 20,4\u00ba, d) salt acid di - 1 - hydroxy - 2 - naftoico presents a pattern of x-ray Powder diffraction with a specific peak in 2 Theta Like To 8,3\u00ba, 16,6\u00ba 19.4 or 23,4\u00ba,(e) the acid salt monobenzoico presents a pattern of x-ray Powder diffraction with a specific Peak at 2 Theta like a6,3\u00ba, 9,3\u00ba, 17,8\u00ba or 23,8\u00ba. It also relates to a Pharmaceutical composition. These compositions are useful in the treatment of COPD, Asthma, allergic rhinitis, atopic dermatitis, among othersREFERIDA A UNA SAL DE DISACARINA, ACIDO DIFUMARICO, ACIDO DI-1-HIDROXI-2-NAFTOICO O ACIDO MONOBENZOICO DEL 2-(4-((2-AMINO-4-METIL-6-(PENTILAMINO)PIRIMIDIN-5-IL)METIL)FENIL)ACETATO DE 4-(DIMETILAMINO)BUTILO. TAMBIEN ESTA REFERIDA A SALES CRISTALINAS DE DICHO COMPUESTO TALES COMO: a) LA FORMA A DE LA SAL DISACARINA QUE PRESENTA UN PATRON DE DIFRACCION DE RAYOS X EN POLVO CON UN PICO ESPECIFICO EN 2 THETA IGUAL A 9,2º, 14,9º O 15,2º, b) LA FORMA B DE LA SAL DISACARINA QUE PRESENTA UN PATRON DE DIFRACCION DE RAYOS X EN POLVO CON UN PICO ESPECIFICO EN 2 THETA IGUAL A 12,0º, 12,5º, 16,4º O 19,8º, c) LA SAL DE ACIDO DIFUMARICO QUE PRESENTA UN PATRON DE DIFRACCION DE RAYOS X EN POLVO CON UN PICO ESPECIFICO EN 2 THE
