Compositions and methods for lowering IOP and/or providing neuroprotection are disclosed. The compositions and methods are particularly directed to the use inhibitors of Jun N-terminal kinases (JNK) to lower IOP and/or provide neuroprotection.用於降低IOP及/或提供神經保護的組成物和方法被揭露。該等組成物和方法係特別地針對Jun N-端激酶(JNK)抑制劑以降低IOP及/或提供神經保護之用途。