A protein provided is: a) a protein with an amino acid sequence as shown in amino acids 1-264 of SEQ ID NO: 1; b) a protein that is associated with disease resistance and obtained after an amino acid sequence as shown in amino acids 1-264 of SEQ ID NO: 1 in a Sequence Listing is subjected to substitution and/or deletion and/or addition of one or several amino acid residues; c) a protein with an amino acid sequence as shown in SEQ ID NO: 1; or d) a protein that is associated with disease resistance and obtained after the amino acid sequence as shown in SEQ ID NO: 1 in the Sequence Listing is subjected to substitution and/or deletion and/or addition of one or several amino acid residues. Experiments demonstrate that the protein associated with disease resistance and the encoding gene thereof can be used to enhance plant disease resistance.