PD-L1 and PD-L2-based fusion proteins and uses thereof

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专利权人:

THOMAS JEFFERSON UNIVERSITY

发明人:

Mark L. Tykocinski

申请号：

US14763649

公开号：

US09657082B2

申请日:

2014.01.31

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Provided are fusion proteins comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1 and the second domain comprises a polypeptide that binds to and triggers a TRAIL receptor or Fas. In some embodiments, the polypeptide that binds to and triggers PD-1 comprises at least a portion of the extracellular domain of PD-L1 or PD-L2 and the second domain comprises at least a portion of the extracellular domain of TRAIL or Fas ligand. Also provided are methods for treating autoimmune, alloimmune or inflammatory diseases, and methods for treating cancer, using the fusion proteins.

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