Christian GIEFFERS,Oliver HILL,Meinolf THIEMANN,Tim SCHNYDER
申请号：
US15955086
公开号：
US20180237495A1
申请日:
2018.04.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are specific CD137 receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a CD137L-associated disease or disorder. The CD137 receptor agonist proteins provided herein comprise three soluble CD137L domains and an Fe fragment. The CD137 receptor agonist proteins are substantially non-aggregating and suitable for therapeuctic, diagnostic and/or research applications.
