STEPANOVA ALENA OLEGOVNA,Степанова Алёна Олеговна,CHERNONOSOVA VERA SERGEEVNA,Черноносова Вера Сергеевна,POPOVA IRINA VLADIMIROVNA,Попова Ирина Владимировна,KARPENKO ANDREJ ANATOLEVICH,Карпенко Андрей
申请号：
RU2014143589/15
公开号：
RU0002572333C1
申请日:
2014.10.28
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
FIELD: medicine.SUBSTANCE: what is described is a method, which involves dissolving initial synthetic polymer and protein in hexafluorisopropanol, mixing the polymer solution and the protein solution in polymer: protein ratio (7-9):(1-3) according to the first version, at the first stage of electrospinning, a collection electrode is coated with the prepared composition in an amount of 1.0-10.0% of the required volume a formed inner layer of the prosthesis is impregnated with the protein solution in the concentration of 1.0-5.0% at the second stage, the formed inner layer is coated with leftover 90-99% of the composition, and an outer layer of the prosthesis is formed. According to the second version of the method, the formed inner layer of the prosthesis making 0.1-90.0% of a pre-set thickness of a prosthesis wall is coated with the composition containing a mix of polymer and protein in polymer: protein ratio (1-3):(1-7), and an intermediate layer making 0.1-10.0% of the pre-set thickness of the prosthesis wall is formed it is coated with the leftover amount of the composition to form an outer layer of the prosthesis making 9.0-98.9% of the pre-set thickness of the prosthesis wall different polymers may be used to form the outer and inner layers of the prosthesis.EFFECT: producing small-diameter low-porosity vascular prostheses, improving their strength and flexibility characteristics, as well as bio- and haemocompatibility of the vascular prostheses.4 cl, 2 dwg, 7 exГруппа изобретений относится к области медицины. Описан способ, который включает растворение исходного синтетического полимера и белка в гексафторизопропаноле, смешивание раствора полимера с раствором белка в соотношении полимер : белок, равном (7-9):(1-3), при этом согласно первому варианту на первом этапе электроспиннинга на электрод-коллектор наносят 1,0-10,0% от требуемого объема раствора полученной композиции, затем сформированный внутренний слой протеза пропитывают раствором белка в концентрации 1
