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HYBRID PROTEIN FROM ANTIBODIES AGAINST MHC AND ANTIVIRAL CYTOKINE
专利权人:
Ф. ХОФФМАНН-ЛЯ РОШ АГ
发明人:
ЕНЕВАЙН Стефан,КОПЕЦКИ Эрхард,РИС Стефан,ТИФЕНТАЛЕР Георг
申请号:
RU2013106217
公开号:
RU2013106217A
申请日:
2011.08.03
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A fusion protein containing an antibody that specifically binds to the main human histocompatibility complex, presenting a peptide fragment of the hepatitis B virus protein, and an antiviral cytokine. The fusion protein according to claim 1, characterized in that the peptide fragment of the hepatitis B virus protein has an amino acid sequence corresponding to amino acid residues 182-190 of the sequence SEQ ID NO: 01 or amino acid residues 18-27 of the sequence SEQ ID NO: 02.3. The fusion protein according to claim 1, characterized in that the antibody specifically binds to hepatocytes infected with hepatitis B virus. The fusion protein according to claim 1, characterized in that the antiviral cytokine is selected from interferons of type I and (or) II.5. The fusion protein according to claim 1, characterized in that the fusion protein has the same specificity as T cells carrying CD8.6. The fusion protein according to claim 1, characterized in that the antibody does not have the ability to specifically bind to serum hepatitis B.7 antigens. The fusion protein of claim 1, wherein the antibody is a monoclonal antibody. The fusion protein according to claim 1, characterized in that the antibody is a human, humanized or chimeric antibody. The fusion protein according to claim 1, characterized in that the antibody is an antibody fragment that specifically binds to the main histocompatibility complex of a person presenting a peptide fragment of the hepatitis B virus protein. The fusion protein according to claim 1, characterized in that the antibody contains: a) CDR-H3 containing the amino acid sequence of SEQ ID NO: 06, b) CDR-L3 containing the amino acid sequence of SEQ ID NO: 10 and c) CDR-H2, containing amino acid1. Слитый белок, содержащий антитело, которое специфически связывается с главным комплексом гистосовместимости человека, презентирующим пептидный фрагмент белка вируса гепатита B, и антивирусный цитокин.2. Слитый белок по п.1, отличающийся тем, что пептидный
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