The present invention relates to a method for treating symptoms from a nicotine withdrawal comprising administering to a patient an effective amount of a transdermal compound. In one embodiment the compound includes the following active ingredients: Sertraline, Imipramine, Topiramate, and Bupropion, while in another embodiment the active ingredients are: Fluoxetine, Nortriptyline, Topiramate, and Bupropion.