WEISS, MATTHEW,BOEZIO, ALESSANDRO,BOEZIO, CHRISTIANE,BUTLER, JOHN R.,CHU-MOYER, MARGARET YUHUA,DIMAURO, ERIN F.,DINEEN, THOMAS,GRACEFFA, RUSSELL,GUZMAN-PEREZ, ANGEL,HUANG, HONGBING,KREIMAN, CHARLES,LA
申请号：
TW103120411
公开号：
TW201536768A
申请日:
2014.06.12
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.本發明提供式I化合物，□及其醫藥上可接受之鹽，其係電壓門控鈉通道、尤其Nav1.7之抑制劑。該等化合物可用於治療與鈉通道之活性相關之疾病，例如疼痛病症及癢症。本發明亦提供含有本發明化合物之醫藥組合物。
