The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.本發明提供化合物、包含此等化合物之醫藥組合物,及使用此等化合物治療或預防與異常或失調之TRK激酶活性相關之疾病或病症的方法。