ROUSH, WILLIAM R.,罗西 威廉 Ｒ,羅西 威廉 Ｒ,VENKATRAMAN, SHANKAR,文卡特曼 山可,GLICK, GARY,格利克 盖瑞,格利克 蓋瑞,SEIDEL, HANS MARTIN,赛德 汉斯 马汀,賽德 漢斯 馬汀
申请号：
TW108123334
公开号：
TW202014408A
申请日:
2019.07.02
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.本揭示內容係關於抑制(例如拮抗)干擾素基因刺激物(Stimulator of Interferon Genes, STING)之化學實體(例如，化合物或該化合物之醫藥上可接受之鹽及/或水合物及/或共晶體及/或藥物組合)。該等化學實體可用於例如治療個體(例如人類)之病症、疾病或病況，其中因提高(例如，過度)之STING活化(例如STING信號傳導)而助長該病症、疾病或病況(例如癌症)之病理學及/或症狀及/或進展。本揭示內容亦係關於含有其之組合物以及其使用及製備方法。
