雙環芳基及雜芳基化合物之鈉通道抑制劑农业专利-农业学术服务平台

发明人:: BOEZIO, CHRISTIANE,伯西欧　克利斯汀安,伯西歐　克利斯汀安,BREGMAN, HOWARD,布莱曼　霍尔,布萊曼　霍爾,COATS, JAMES R.,寇斯　詹姆斯Ｒ,DIMAURO, ERIN F.,戴莫卢　艾林Ｆ,戴莫盧　艾林Ｆ,DINEEN, THOMAS,戴宁　汤玛斯,戴寧　湯瑪斯,DU, BINGFAN,都　彬梵,GRACEFFA, RUSSE,伯西欧克利斯汀安,伯西歐克利斯汀安,布莱曼霍尔,布萊曼霍爾,寇斯詹姆斯R,戴莫卢艾林F,戴莫盧艾林F,戴宁汤玛斯,戴寧湯瑪斯,都彬梵

摘要：: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.本發明提供式I化合物或其醫藥學上可接受之鹽，其為電壓門控鈉通道、尤其Nav 1.7之抑制劑。該等化合物適用於治療可藉由抑制鈉通道治療之疾病，諸如疼痛病症。亦提供含有本發明之化合物之醫藥組合物。