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METHODS OF OVERCOMING IMMUNOLOGICAL TOLERANCE USING MULTIPLE GUIDING RNA
专利权人:
ИНК. (US);РЕГЕНЕРОН ФАРМАСЬЮТИКАЛС
发明人:
ВОРОНИНА Вера (US),МАКДОНАЛД Линн (US),ПРИССЕТТ Марин (US),ЛАЙ Ка-Ман Венус (US),БАДИТ Ашок (US),МЕРФИ Эндрю Дж. (US),ДРОГЕТТ Густаво (US),ФРЭНДЭВЕЙ Дэвид (US),ЗАМБРОВИЧ Брайан (US)
申请号:
RU2018143655
公开号:
RU2018143655A
申请日:
2017.05.19
申请国别(地区):
RU
年份:
2020
代理人:
摘要:
Methods and compositions are provided for making non-human animals with reduced tolerance of a foreign antigen of interest and making antigen-binding proteins against that foreign antigen of interest using such animals. The methods and compositions employ CRISPR/Cas9 systems using multiple guide RNAs to reduce or eliminate expression of a self-antigen homologous to or sharing an epitope of interest with the foreign antigen of interest or to reduce or eliminate expression of an epitope on the self-antigen that is shared with the foreign antigen of interest.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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