VORONINA, Vera,MACDONALD, Lynn,PRISSETTE, Marine,LAI, Ka-Man Venus,BADITHE, Ashok,MURPHY, Andrew J.,DROGUETT, Gustavo,FRENDEWEY, David,ZAMBROWICZ, Brian
申请号：
SG11201809552S
公开号：
SG11201809552SA
申请日:
2017.05.19
申请国别(地区):
SG
年份:
2018
代理人:
摘要：
Methods and compositions are provided for making non-human animals with reduced tolerance of a foreign antigen of interest and making antigen-binding proteins against that foreign antigen of interest using such animals. The methods and compositions employ CRISPR/Cas9 systems using multiple guide RNAs to reduce or eliminate expression of a self-antigen homologous to or sharing an epitope of interest with the foreign antigen of interest or to reduce or eliminate expression of an epitope on the self-antigen that is shared with the foreign antigen of interest.
