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Bi- and tricyclic fused pyrimidines as tyrosine kinase inhibitors
专利权人:
Tomoyasu Ishikawa;Hiroshi Banno;Masaki Seto
发明人:
Tomoyasu Ishikawa,Hiroshi Banno,Masaki Seto
申请号:
US12172631
公开号:
US08178543B2
申请日:
2008.07.14
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a compound represented by the formula:wherein W is C(R1) or N, each A is an optionally substituted aryl group or a heteroaryl group, X1 is —NR3—Y1—, —O—, —S—, —SO—, —SO2— or —CHR3— wherein R3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R3 is optionally bonded to A to form an optionally substituted ring structure, R1 is a hydrogen atom or an optionally substituted group bonded via a carbon atom, a nitrogen atom or an oxygen atom, R2 is a hydrogen atom or optionally substituted group bonded via a carbon atom or a sulfur atom, or R1 and R2, or R2 and R3 are optionally bonded to form an optionally substituted ring structure, or a salt thereof, and a tyrosine kinase inhibitor or an agent for the prophylaxis or treatment of cancer, which contains this compound or a prodrug thereof.
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