WISSNER, ALLAN,TSOU, HWEI-RU,BERGER, DAN MAARTEN,FLOYD, MIDDLETON BRAWNER JR.,HAMANN, PHILIP ROSS,ZHANG, NAN,FROST, PHILIP
申请号：
ES10173332
公开号：
ES2457396T3
申请日:
1999.09.22
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of Formula 1 having the structure: ** Formula ** in which: X is optionally monosubstituted, disubstituted or trisubstituted phenyl with a substituent selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, azido, hydroxyalkyl of 1-6 carbon atoms, halomethyl, alkoxymethyl of 2-7 carbon atoms, alkanoyloxymethyl of 2-7 carbon atoms, alkoxy of 1 -6 carbon atoms, alkylthio of 1-6 carbon atoms, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy of 2-7 carbon atoms, carboalkyl of 2- 7 carbon atoms, phenoxy, phenyl, thiophenoxy, benzoyl , benzyl, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 2 to 12 carbon atoms, phenylamino, benzylamino, alkanoylamino of 1-6 carbon atoms, alkenylamino of 3-8 carbon atoms, alkylamino of 3-8 carbon atoms, carboxyalkyl of 2-7 carbon atoms, carboalkoxyalkyl of 3-8 carbon atoms, aminoalkyl of 1-5 carbon atoms, Nalkylaminoalkyl of 2-9 carbon atoms, N, N-dialkylaminoalkyl of 3-10 carbon atoms, N alkylaminoalkoxy of 2-9 carbon atoms, N, N-dialkylaminoalkoxy of 3-10 carbon atoms, mercapto and benzoylamino； Z is -NH； each R1 and R4 is H； G1 is hydrogen, halogen, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, alkenyloxy of 2-6 carbon atoms, alkynyloxy of 2-6 carbon atoms , hydroxymethyl, halomethyl, alkanoyloxy of 1-6 carbon atoms, alkenyloxy of 3-8 carbon atoms, alkynyloxy of 3-8 carbon atoms, alkanoyloxymethyl of 2-7 carbon atoms, alkenyloxymethyl of 4-9 carbon atoms, alkyloxymethyl of 4-9 carbon atoms, alkoxymethyl of 2-7 carbon atoms, alkoxy of 1-6 carbon atoms, alkylthio of 1-6 carbon atoms, alkylsulfinyl of 1-6 carbon atoms, alkylsulfonyl of 1-6 carbon atoms, alkylsulfonamido of 1-6 carbon atoms, alkenylsulfonamido of 2-6 carbon atoms, alkynylsulfonamido of 2-6 carbon atoms, hydroxy, trifluoromethyl, trifluoromethoxy, cyano, nitro, carboxy, carboalkoxy of 2-7 atoms of carbon, carboalkyl of 2-7 carbon at
