IVACHTCHENKO, Alexandre Vasilievich,ИВАЩЕНКО, Александр Васильевич,BICHKO, Vadim Vasilievich,БЫЧКО, Вадим Васильевич,MITKIN, Oleg Dmitrievich,МИТЬКИН, Олег Дмитриевич
申请号：
RURU2011/000533
公开号：
WO2012/011847A1
申请日:
2011.07.19
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to novel antiviral active components of general formula 1, a pharmaceutical composition, an antiviral drug and a method for preventing and treating viral diseases, in particular diseases caused by the hepatitis C virus (HCV). In general formula 1, R1 is a hydrogen atom, optionally substituted C1–C4 alkyl, C6 cycloalkyl, aryl, ethoxycarbonyl, a nitro group R2 is a hydrogen atom R3 is N-monosubstituted or NN-disubstituted 1-methylene-piperidine-3-carboxamide of general formula 1a or N-monosubstituted or NN-disubstituted 1-methylene-piperidine-4-carboxamide of general formula 1b R4 is a hydrogen atom, optionally substituted C1-C3 alkyl or R2 and R3 together with the carbon atoms to which they are bonded form substituted 2,3,4,9-tetrahydro-1H-carbazole of general formula 1.1, or R2, R3 and R4 together with the atoms to which they are bonded form a substituted nitrogen heterocycle of general formula 1.2 R5 and R6 are optionally identical and are a hydrogen atom, optionally substituted C1-C3 alkyl or C3-C6 cycloalkyl, or R5 and R6 together with the nitrogen atom to which they are bonded form an optionally substituted 5 or 6-membered nitrogen heterocycle which contains one or two nitrogen atoms and may be condensed with a benzene ring R7 and R8 are hydrogen atoms, or R7 and R8 together with the carbon atom to which they are bonded form a C=O group R9 is a nitrogen heterocycle containing at least one nitrogen atom, unsubstituted formamide, or phenyl, a substituted ethoxycarbonyl or nitro group R10 is a hydrogen atom, optionally substituted C1-C3 alkyl, substituted acetyl n = 1 or 2 and a broken line with an accompanying continuous line (---) represents a single or double bond.La présente invention concerne de nouveaux composants actifs antiviraux de formule générale 1, une composition pharmaceutique, un médicament antiviral et un procédé de prévention et de traitement de maladies virales, notamment de maladies provoquées par le virus de lhépati
