FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula I:,where X1 denotes a bond, NR8 or S； Y1 denotes O or NR ； R1 denotes C1-10alkyl, C6-10aryl or a 5-10-member heteroaryl containing 1-3 heteroatoms which are independently selected from N or S； where said R1 is optionally substituted with 0-2 J1； R2 denotes H or C1-10alkyl； each of R3, R4, R5 and R6 independently denotes H or C1-10alkyl； and R7 denotes C1-10alkyl, C3-10cycloalkyl, phenyl, 5-6-member heterocyclyl containing 1-3 heteroatoms independently selected from O and N, - (C1-6alkyl) -(C3-10cycloalkyl), - (C1-6alkyl) - (phenyl) or -(C1-6alkyl)-(6-member heterocyclyl containing 2 heteroatoms selected from O and N)； where said R7 is optionally substituted with 0-5 J7； or R3 and R4, together with a carbon atom with which they are bonded, optionally form a 3-4-member saturated or partially unsaturated monocyclic fragment； R3 and R5, together with carbon atoms with which they are bonded, optionally form a 5-member monocyclic fragment； R8 denotes H； R9 denotes H or unsubstituted C1-6alkyl； or R2 and R9, together with atoms with which they are bonded, optionally form a 5-member aromatic monocyclic fragment containing 3 nitrogen atoms； each J1 independently denotes C1-6halogenalkyl, halogen, NO2, CN, Q or -Z-Q； or two J1 together can optionally form =O； Z denotes C1-6alkyl, wherein 0-3 carbon atoms are optionally substituted with -NR-, -O-, -C(O)- or -SO2-； wherein each Z is optionally substituted with 0-2 J2； Q denotes H； C1-6alkyl； 3-8-member aromatic or non-aromatic monocyclic fragment containing 0-3 heteroatoms independently selected from O, N and S； or an 8-10-member aromatic bicyclic system； each Q is optionally substituted with 0-2 JQ； each J7 independently denotes C1-6alkyl or halogen(C1-4alkyl)； each of JQ and J7 independently denotes M or -Y-M； each Y independently denotes an unsubstituted C1-6alkyl, wherein 0-3 carbon atoms are optionally substituted with -O-, -C(O)- or -SO2-； each M indep
