Herdewijn, Piet,de Jonghe, Steven,Gao, Ling-Jie,Jang, Mi-Yeon,Vanderhoydonck, Bart,Waer, Mark Jozef Albert,Lin, Yuan,Herman, Jean Ferdinand,Louat, Thierry Andre Michel
申请号：
ES15162142
公开号：
ES2665277T3
申请日:
2010.03.15
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound, having the general formula III or IV: ** (See formula) ** in which - R12 is represented by the general formula V: ** (See formula) ** and in which it schematically represents a heterocyclic ring saturated or partially unsaturated with at least two nitrogen atoms in said heterocyclic ring and with a total of 5 to 7 atoms in said heterocyclic ring and, optionally, with one or more other heteroatoms in said heterocyclic ring or attached to one or more atoms of carbon of said heterocyclic ring, in which one of said at least two nitrogen atoms in the heterocyclic ring is attached to a carbon atom 6 of the purine ring； - each R13 substituent on the heterocyclic ring is a group independently selected from the group consisting of halogen, nitro, C1-7alkyl (optionally containing one or more functions or radicals selected from the group consisting of halogen, carbonyl, thiocarbonyl, hydroxyl , sulfhydryl, C1-7 alkoxy, acetal, thioacetal, imino, oximino, alkyloxymine, amino acid, cyano, (thio) carboxylic acid, ester or amide of (thio) carboxylic acid, nitro, amino, C1-7 alkylamino, cycloalkylamino, alkenylamino , cycloalkenylamino, alkynylamino, arylamino, arylalkylamino, hydroxyalkylamino, mercaptoalkylamino, heterocyclic-substituted alkylamino, arylamino substituted heterocyclic, hydrazino, alkylhydrazino, phenylhydrazino, sulfunilo and sulfonamido), C3-7 alkenyl, C2-7 alkynyl, haloalkyl, C3 -10, aryl, arylalkyl, alkylaryl, alkylacyl, arylacyl, hydroxyl, sulfhydryl, amino, C1-7 alkylamino, cycloalkylamino, alkenylamin or, cycloalkenylamino, alkynylamino, arylamino, arylalkylamino, hydroxyalkylamino, mercaptoalkylamino, heterocyclic-substituted alkylamino, arylamino substituted heterocyclic, hydrazino, alkylhydrazino, phenylhydrazino, C1-7 alkoxy, C3-10 cycloalkoxy, aryloxy, arylalkyloxy, alkyloxy substituted heterocyclic, arylalkylthio , heterocyclic substituted alkylthio, formyl, hydroxyamino, cyano, (thio) carboxylic acid or its esters or thioesters or amides o
