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Mitochondrial inhibitors for the treatment of diffusion disorders
专利权人:
BASILEA PHARMACEUTICA INTERNATIONAL AG
发明人:
申请号:
ARP180102923
公开号:
AR113437A1
申请日:
2018.10.10
申请国别(地区):
AR
年份:
2020
代理人:
摘要:
Claim 1: a compound of formula (1) or formula salt, wherein ring a represents a group of formula (2),(3)O(4);A1 representative-c (r8308 No. 74919) (r8308; 74919);-C(R8308;=7491);-N(R8308;74955)-,-N-O-O-SA2 stands for - C (R83087880) (R8308; (758080) -,-C(R8308;=7580)=U-O-;A3 = for - C (r83080; - 758080) (r8308; - 758080);-C(R8308;=7580)=U-O-;A8308OLA-C(R8308;;74919)(R8308;-74919);-C(R8308;=7491);-N-O-O-SA830909OA-C(R8308;;74919)(R8308;-74919);-C(R8308;=7491);-N(R8308;74955)-,-N-O-O-SA8310 represents - C (r8308;; 758080) (r8308;; 758080) - O-C (r8308;; 758080) =;A8311a stands for - C (r8308;; 74919) (r8308; - 74919);-C(R8308;=7491);-N-O-O-SA831222 represents - C (r8308;; 74919) (r8308; - 74919);-N(R8308;74955)-,-O-O-SA8313 stands for - C (r8308;; 758080) (r8308; - U-O -;A1-830404 represents - C (r8308; - 758080) (r8308; - U-O -;A1 1 representative-C(R8308;(758080)(R8308;(758080)-U-O-;A1 2 representative-C(R8308”;(R8308;-74919);-O-O-SWhere formula group (2),Formula group (3) and formula group (4) do not contain adjacent oxygen atoms, adjacent oxygen and sulfur atoms or adjacent oxygen and nitrogen atoms, or a selected group of other parts composed of n-c-n, n-c-s, s-c-s, o-c-n, O-C-O and o-c-s. in each case, the remaining carbon atoms in n-c-n and n-c-s, S-c-s, o-c-n, O-C-O and o-c-s saturation; B 1,B.,B ° and B ° 830808 independently represent C (R3) or N, not more than 2 of which are B1,B.,B ° and B ° 830808m represent n; X represents - CH (r83099) -,-C(R83099)=1-C(o)-o-oWhen x stands for - CH (r83099),-C(o)-U(o)When X represents - C (r83099) =, the dotted line represents a simple connection.a. Point line represents double connection; R1 represents c83218833162622 leased land independently;a. Halogenated tar c833218d83316262 or c833218d83316262;a. One or two carbon atoms are independently replaced by - O -, and the rest of the tar can be replaced by one or more halogens; R2 represents halogen, cyanogen, hydroxyl, mercato, and hydrocarbyl c83321833126;Options 1 to 5
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