DEMEHN SAMJUEHL DOMINIK,ДЕМЭН Самюэль Доминик,MAK GOUEN DEHVID,МАК ГОУЕН Дэвид,LAST STEFAN ZHJULEN,ЛАСТ Стефан Жюльен,RABUASSON PER ZHAN-MARI BERNAR,РАБУАССОН Пьер Жан-Мари Бернар
申请号：
RU2011147726/04
公开号：
RU0002528231C2
申请日:
2010.04.23
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula (I), to its possible stereoisomers, or to its pharmaceutically acceptable salts, where R and R1, independently on each other, represent benzoyl, substituted with one substituent, each of which is independently selected from halogen or -C(=O)-Het, where Het is optionally substituted with two substituents, independently selected from C1-4alkyl, or a group of formula -C(=O)-CH(Rx)-R6, C1-6alkyloxycarbonyl, a group of formula R8-O-C(=O)-HN-CH(R7)-C(=O)- or -C(=O)-C(=O)-phenyl R6 represents C1-4alkyl, C3-6cycloalkyl, benzyl or phenyl, where phenyl can be optionally substituted with one, two or three substituents, each of which is independently selected from halogen, C1-6alkyl, methoxy, trifluoromethoxy, or two substituents at adjacent atoms of the ring together with a phenyl ring form benzodioxol, and where C1-4alkyl is substituted with diC1-6alkylamino, phenylsulphonyl, Het, and where benzyl is substituted with one substituent, each of which is independently selected from halogen, methoxy Rx is selected from hydrogen, hydroxyl, diC1-6alkylamino, imidazolyl, Het represents a heterocyclic group, containing one or two heteroatoms, selected from O and N, and containing 5-6 atoms in a ring, where the said heterocyclic ring is bound with the carbonyl carbon atom through the ring carbon atom and where at least one of the said heteroatoms is adjacent to the said ring carbon atom, R2 and R3, independently on each other represent hydrogen R4 and R5, independently on each other represent hydrogen or methoxy each R7 independently represents phenyl or C1-4alkyl optionally substituted with methoxy and R8 represents C1-4alkyl. The invention also relates to particular compounds and a pharmaceutical composition based on formula (I) compound.EFFECT: obtained are novel compounds, useful as HCV inhibitors.11 cl, 4 tbl, 49 exИзобретение относится к соединению формулы (I), к его возможным стереоизомерам, или к его фармац
