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Quinine-2-ona derivative
专利权人:
MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
发明人:
DRA. ESDAR, CHRISTINA,DR. CZODROWSKI, PAUL,DRA. WUCHERER-PLIETKER, MARGARITA,DR. BURGDORF, LARS,MUZERELLE, MATHILDE,DR. DORSCH, DIETER
申请号:
ARP170100065
公开号:
AR107335A1
申请日:
2017.01.11
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
Claim 1: formula compound (1),In which x1,X2,X3,Each of x830808 is independent,1. Denotes ch or N; and denotes n or CH; Q denotes h or CH 832323;R1 means h, F, Cl, Br, CN, ch832323,CF8323U OC832323;R: for H, f or Cl; R3 for phenyl, nafilo, pyridine, pyridyldine, quinoline, isoquinolininilo, indolilo, indazollo, thifennilo, dihydroxyisobutylene or benzimidazolol, each substance has not been replaced by Hal, CN, no83221 or once, twice or three times;A (CR) OR(CR) N (R)(CR) S (O) R(CR) CON (R)(CR) COHet (CR) SO N (R)(CR) SO Het (CR) N (R)(c) People people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people people (H) 832222;(CR) N (R) COA (CR) N (R) COHet(CR 83088) - 8345 ocyc and / or (CR 83088) - 8345 cour8308;R8308 means h or a ';A refers to the unbundled or branched tar with 1-10 C atoms. In this case, two adjacent carbon atoms can form a double-sided link and / or one or two non adjacent CH and / or CH 832222 groups, which can be replaced by N or Y / or S atoms, of which 1-7 H atoms can be replaced by r83099;O periodic tar, containing 3-7 C atoms; a 'refers to 1-6 C atoms of non diffusive tar or branch tar, in which 1-2 CH and / or ch832222 non adjacent ch groups and / or ch832222 can be replaced by O atoms; CYC refers to cyclohexane, cyclopentadiene or cyclohexane, each of which has no substitute or is replaced by a once or twice, Hal, or830808,N (R)Het',(CR) O (CR) HetCON (R) y 2Fo 3DO R denota F Cl u OH Het denota pirrolidinilo morfolinilo piperidinilo piperazinilo 1 4 -diazepanilo oxazolidinilo hexahidro-pirrolo 3 4-c pirrolilo 2-oxa-6-aza-espiro 3 4 octanilo 2-oxa-6- OCOA COA (CR) N (R)(CR830808HET)..(CR) O (CR) HetCON (R)Coyt(CR) S (O) RY / o =
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