A method of immunotherapy of a mammal, or a laser device therefor, includes the step of treating one or more immune privileged cells, tissues or organs of said mammal with a laser to reduce or eliminate the immune privilege status of said one or more cells, tissues and/or organs to thereby elicit an immune response that is beneficial to the mammal. The method of immunotherapy avoids or minimizes lasting damage to the treated cells, tissues and/or organs. The laser treatment is typically, although not exclusively, to the pigmented epithelium of the eye or eyes. The method may be for treating a disease or condition selected from: a bacterial infection a viral infection early AMD glaucoma diabetic retinopathy multiple sclerosis Parkinsons disease and Alzheimers disease. Typically, the radiant exposure level of the laser treatment is no greater than 60-100% of a visible effect threshold.
