A method of immunotherapy of a mammal or a laser device therefor, includes the step of treating one or more immune privileged cells, tissue or organs of said mammal with a laser to reduce or eliminate the immune privilege status of said one or more cells, tissues and/or organs to thereby elicit an immune response that is beneficial to the mammal. The method of immunotherapy avoids or minimizes lasting damage to the treated cells, tissues and/or organs. The laser treatment is typically, although not exclusively to the pigmented epithelium of the eye or eyes. The method may be for treating a disease or conditions selected from a bacterial infection, a viral infection, early AMD, glaucoma, diabetic retinopathy, multiple sclerosis, Parkinsons disease, and Alzheimers disease. Typically, the radiant exposure level of the laser treatment is no greater than 60-100% of a visible effect threshold.
