Richard Beliveau,Michel Demeule,Stephane Barakat,Jonathan Michaud-Levesque
申请号：
US12446434
公开号：
US08487072B2
申请日:
2007.10.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention is directed to polypeptides (e.g., fragments) derived from P-glycoprotein and caveolin-1 which are capable of inhibiting the interaction between these two proteins. Inhibition of this interaction leads to increase of efflux of compounds that are transported by P-gp. The invention further includes methods of treating patients having diseases that benefit from increased P-gp-mediated efflux. Such diseases include neoplasms such as cancer and neurological diseases such as neurodegenerative diseases.
