The present invention belongs to the field of drug, health-nutrition replenishers and chemical industry. Specifically, the present invention relates to a kind of herbal-compositions, the herbal-composition eliminates the A β increasing action of existing treatment, and the modulability processing for acting on what amyloid protein-β amyloid protein precursor (APP), thus provides a kind of significant more effective treatment with what neurodegenerative disease unrelated with any beta-amyloid protein increasing action.本發明屬於藥物、健康營養補充劑以及化學工業的領域。具體來說,本發明涉及一種草藥組合物,所述草藥組合物消除了現有治療的Aβ增加作用,並且作用於澱粉樣蛋白-β蛋白前體(APP)的調節性加工,因此提供了一種與任何β-澱粉樣蛋白增加作用無關的顯著更有效用於神經變性疾病的治療。