The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.本發明提供新穎的普拉二烯內酯化合物、含有此類化合物之醫藥組合物及使用該等化合物作為治療劑之方法。此等化合物可用於治療癌症，特別是已知靶向剪接體及其中突變之藥劑為有用的癌症。本文亦提供藉由投與本文所揭示之至少一種化合物及至少一種額外療法來治療癌症之方法。
