In one aspect, the present disclosure provides caffeic acid derivatives of the formula:,wherein the variables are as defined herein. In another aspect, the present disclosure provides pharmaceutical compositions and methods of using of the compounds disclosed herein, including for the treatment of cancer.於一態樣中,本發明提供下式之咖啡酸衍生物:,其中變數係如本文中所定義。於另一態樣中,本發明提供醫藥組合物及使用本文中所揭示之化合物之方法,包括用於治療癌症。