The present disclosure relates to a pharmaceutical combination comprising (a) an Mdm2 inhibitor and (b)(i) a MEK inhibitor and/or (b)(ii) Bcl2 inhibitor, particularly for use in the treatment of a cancer. This disclosure also relates to uses of such combination for preparation of a medicament for the treatment of a cancer； methods of treating a cancer in a subject in need thereof comprising administering to said subject a jointly therapeutically effective amount of said combination； pharmaceutical compositions comprising such combination and commercial packages thereto.
