TSCHOEPE, MARKUS,KRAUSE, HANS-JUERGEN,BARTL, ANNIKA,KALETA, KATHARINA,FRAUNHOFER, WOLFGANG
申请号：
NZ58570208
公开号：
NZ585702A
申请日:
2008.11.28
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
585702 Disclosed herein are aqueous formulations comprising water and at least about 20 mg/mL of an antibody, or antigen-binding fragment thereof, wherein the antibody, or antigen-binding fragment thereof, has a hydrodynamic diameter (Dh) which is at least about 50% less than the Dh of the antibody or had a hydrodynamic diameters of less than about 4 nm, or antigen-binding fragment thereof, in a buffered solution at the same concentration, and the antibody, or antigen-binding fragment thereof, has a molecular weight (Mw) greater than about 47 kDa. Specifically, wherein the antibody, or antigenbinding fragment thereof, is selected from the group consisting of adalimumab, alemtuzumab, CEA-Scan Arcitumomab (fab fragment), cetuximab, trastuzumab, imciromab pentetate, capromab pendetide, infliximab, abciximab, rituximab, basiliximab, palivizumab, nofetumomab, omalizumab, daclizumab, ibritumomab tiuxetan, muromonab-CD3, edrecolomab, gemtuzumab ozogamicin, golimumab, certolizumab pegol, eculizumab, ustekinumab, panitumumab, tositumomab and I131 tositumomab, and bevacizumab.
