GUENTHER, RALF,BECKER, STEFAN,RHIEL, LAURA,HOCK, BJOERN,SCHROETER, CHRISTIAN
申请号：
CA2953714
公开号：
CA2953714A1
申请日:
2015.06.26
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention relates to anti-TNFa antibodies which are engineered to exhibit a pH-sensitive antigen binding. The invention is preferably directed to anti-TNFa antibody adalimumab (Humira®) or biologically active variants and fragments thereof, wherein the original adalimumab antibody or variant or fragment thereof is engineered by modifications of amino acid sequence within the variable regions. Specifically, the invention relates to adalimumab or biologically active variants or fragments thereof, wherein the CDR domains are modified by replacing one or more amino acid residues by histidine residues.
